It's type of inherited fever which affecting the peritoneal linning of stomach,chest and joints.characterized by Frequent episodes of fever and inflammation.It's called Familial mediterranean fever "FMF" as it's iherited through family.episodes attacks may last for 12-72 hours.maybecamed in first age or most cases in old age.FMF affecting mainly persons living arround mediterranean sea.
MEFV gene mutation is the cause of FMF,MEFV is responsible for pyrine synthesis . pyrine is an immune protein helping in regulation of inflammation process. Mutations in the MEFV gene reduce the activity of the pyrin protein, which disrupts control of the inflammation process
Symptoms mediterranean fever:
1- Severe abdominal pain
2-High fever
3- Chest pain
Diagnosis of FMF:
As genetic disease any test may not useful in it but by some blood tests which affected by FMF as
1-CBC "complete blood count".
2- ESR "erythrocyt sedimentation rate".
3-CR protein.
Treatment of FMF:
treatment purpose is to prevent and decrease symptoms. Colchicin is the used treatment which decrease inflammation and decrease episodes. colchicin my helping in decrease amyloidosis.
MEFV gene mutation is the cause of FMF,MEFV is responsible for pyrine synthesis . pyrine is an immune protein helping in regulation of inflammation process. Mutations in the MEFV gene reduce the activity of the pyrin protein, which disrupts control of the inflammation process
Symptoms mediterranean fever:
1- Severe abdominal pain
2-High fever
3- Chest pain
Diagnosis of FMF:
As genetic disease any test may not useful in it but by some blood tests which affected by FMF as
1-CBC "complete blood count".
2- ESR "erythrocyt sedimentation rate".
3-CR protein.
Treatment of FMF:
treatment purpose is to prevent and decrease symptoms. Colchicin is the used treatment which decrease inflammation and decrease episodes. colchicin my helping in decrease amyloidosis.
